Detailed view for Bm1_45420

Basic information

TDR Targets ID: 235094
Brugia malayi, A-kinase anchor protein 10, precursor
Source Database / ID:  GenBank

pI: 6.4984 | Length (AA): 478 | MW (Da): 53944 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00615   Regulator of G protein signaling domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0004871   signal transducer activity  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
160 313 2af0 (A) 63 201 24.00 0 1 0.617976 -0.8
179 314 4igu (A) 17 144 21.00 0 0.97 0.622319 -1.07
179 314 2bt2 (A) 57 184 20.00 0 1 0.664319 -1.56
181 319 2jnu (A) 8 136 30.00 0.00013 1 0.645695 -0.54

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_134157)

Species Accession Gene Product
Brugia malayi Bm1_45420   A-kinase anchor protein 10, precursor
Caenorhabditis elegans CELE_B0336.4   Protein RGS-5, isoform A
Drosophila melanogaster Dmel_CG4132   CG4132 gene product from transcript CG4132-RA
Echinococcus granulosus EgrG_000727850   A kinase anchor protein 10 mitochondrial
Echinococcus multilocularis EmuJ_000727850   A kinase anchor protein 10, mitochondrial
Homo sapiens ENSG00000108599   A kinase (PRKA) anchor protein 10
Loa Loa (eye worm) LOAG_14060   hypothetical protein
Loa Loa (eye worm) LOAG_02229   hypothetical protein
Mus musculus ENSMUSG00000047804   A kinase (PRKA) anchor protein 10

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Bm1_45420 (Brugia malayi), A-kinase anchor protein 10, precursor
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